STACY A. MALAKER, PH.D.
I obtained my bachelor’s degree from the University of Michigan in Biochemistry and Anthropology-Zoology. During this time, I worked in a core facility, performing peptide synthesis and using mass spectrometry for quality control. This experience led me to the University of Virginia, where I received my PhD from Professor Donald Hunt, one of the founding fathers of biological proteomics. There, my thesis work focused on enrichment and mass spectrometric identification of glycopeptides presented by the MHC class I and II processing pathways. As I was intrigued by the complex role of aberrant glycosylation in cancer, I joined Professor Carolyn Bertozzi’s laboratory at Stanford University as an NIH postdoctoral fellow. My work there used mass spectrometry and glycobiology to characterize mucinase activity on glycoproteins.
My expertise in MS instrumentation and data analysis, combined with my experience in chemical biology and glycobiology, gives my laboratory a unique ability to tackle long-standing challenges associated with glycoproteomics. Here at Yale, my laboratory will be focused on establishing methods and technology to study mucins, a class of densely O-glycosylated extracellular proteins, by MS. We will also study mucins in a biological context, since these proteins are integral in numerous diseases including cancer, cystic fibrosis, and inflammatory bowel diseases (IBD).