STACY A. MALAKER, PH.D.

Dr. Stacy Malaker is an Associate Professor of Chemistry at Yale University, where her laboratory develops next-generation mass spectrometry and chemical glycobiology technologies to study mucin-domain glycoproteins and the broader glycocode. Her research integrates glycoproteomic method development, mucinase engineering, spatial glycoproteomics, and chemical biology to understand how glycosylation regulates protein structure, immune signaling, and disease.

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Since establishing her independent laboratory in 2021, Dr. Malaker has helped pioneer the emerging field of mucinomics through the development of widely adopted analytical workflows and biochemical tools for studying densely O-glycosylated proteins. Her group has applied these technologies to diverse biological systems including immune checkpoint receptors, tear fluid glycoproteins, mucosal biology, ovarian cancer biomarkers, and inflammatory disease. Her work has been published in journals including Nature Communications, Nature Methods, Cell, Molecular Cell, PNAS, and Analytical Chemistry.

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Dr. Malaker has received numerous honors recognizing both her scientific contributions and leadership in the field, including the 2026 Camille and Henry Dreyfus Foundation Camille Dreyfus Teacher-Scholar Award, the 2026 ACS David Y. Gin Young Investigator Award, the 2025 International Glycoconjugate Organization Young Glycoscientist Award, the 2024 HUPO Early Career Researcher Manuscript Competition First Place Award, and the 2023 C&EN Talented 12 recognition.

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Prior to Yale, Dr. Malaker completed postdoctoral research with Carolyn Bertozzi at Stanford University and earned her Ph.D. in Chemistry at University of Virginia under the mentorship of Donald Hunt. Her laboratory is committed to advancing glycoproteomics through technology development, interdisciplinary collaboration, and mentorship at the chemistry–biology interface.